Machine learning guided design of high affinity ACE2 decoys for SARS-CoV-2 neutralization

A potential therapeutic candidate for neutralizing SARS-CoV-2 infection is engineering high-affinity soluble ACE2 decoy proteins to compete for binding of the viral spike (S) protein. Previously, a deep mutational scan of ACE2 was performed and has led to the identification of a triple mutant ACE2 v...

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Detalles Bibliográficos
Autores principales: Chan, Matthew C., Chan, Kui. K., Procko, Erik, Shukla, Diwakar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722601/
https://www.ncbi.nlm.nih.gov/pubmed/34981064
http://dx.doi.org/10.1101/2021.12.22.473902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722601/
https://www.ncbi.nlm.nih.gov/pubmed/34981064
http://dx.doi.org/10.1101/2021.12.22.473902

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