Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human Na(V)1.7/Na(V)1.6 Selectivity Ratios

Huwentoxin-IV (HwTx-IV), a peptide discovered in the venom of the Chinese bird spider Cyriopagopus schmidti, has been reported to be a potent antinociceptive compound due to its action on the genetically-validated Na(V)1.7 pain target. Using this peptide for antinociceptive applications in vivo suff...

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Detalles Bibliográficos
Autores principales: Lopez, Ludivine, Montnach, Jérôme, Oliveira-Mendes, Barbara, Khakh, Kuldip, Thomas, Baptiste, Lin, Sophia, Caumes, Cécile, Wesolowski, Steven, Nicolas, Sébastien, Servent, Denis, Cohen, Charles, Béroud, Rémy, Benoit, Evelyne, De Waard, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722715/
https://www.ncbi.nlm.nih.gov/pubmed/34988086
http://dx.doi.org/10.3389/fcell.2021.798588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722715/
https://www.ncbi.nlm.nih.gov/pubmed/34988086
http://dx.doi.org/10.3389/fcell.2021.798588

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