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Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human Na(V)1.7/Na(V)1.6 Selectivity Ratios
Huwentoxin-IV (HwTx-IV), a peptide discovered in the venom of the Chinese bird spider Cyriopagopus schmidti, has been reported to be a potent antinociceptive compound due to its action on the genetically-validated Na(V)1.7 pain target. Using this peptide for antinociceptive applications in vivo suff...
Autores principales: | Lopez, Ludivine, Montnach, Jérôme, Oliveira-Mendes, Barbara, Khakh, Kuldip, Thomas, Baptiste, Lin, Sophia, Caumes, Cécile, Wesolowski, Steven, Nicolas, Sébastien, Servent, Denis, Cohen, Charles, Béroud, Rémy, Benoit, Evelyne, De Waard, Michel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722715/ https://www.ncbi.nlm.nih.gov/pubmed/34988086 http://dx.doi.org/10.3389/fcell.2021.798588 |
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