Cargando…
A one-step platform for screening high-efficient and minimal off-target CRISPR/Cas13 crRNAs to eradicate SARS-CoV-2 virus for treatment of COVID-19 patients
Coronavirus disease 2019 (COVID-19) is a new respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and now spreads globally. Currently, therapeutics and effective treatment options remain scarce and there is no proven drug to treat COVID-19. Targeting the pos...
Autores principales: | Li, Pu-Yu, Li, San-Qiang, Gao, She-Gan, Dong, Dao-Yin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8723761/ https://www.ncbi.nlm.nih.gov/pubmed/35002020 http://dx.doi.org/10.1016/j.mehy.2021.110754 |
Ejemplares similares
-
PrimedSherlock: a tool for rapid design of highly specific CRISPR-Cas12 crRNAs
por: Mann, James G., et al.
Publicado: (2022) -
CRISPR-Cas-Docker: web-based in silico docking and machine learning-based classification of crRNAs with Cas proteins
por: Park, Ho-min, et al.
Publicado: (2023) -
Structural constraints and enzymatic promiscuity in the Cas6-dependent generation of crRNAs
por: Reimann, Viktoria, et al.
Publicado: (2017) -
CRISPR-Cas12a nucleases function with structurally engineered crRNAs: SynThetic trAcrRNA
por: Jedrzejczyk, D. J., et al.
Publicado: (2022) -
Engineering CRISPR-Cpf1 crRNAs and mRNAs to maximize genome editing efficiency
por: Li, Bin, et al.
Publicado: (2017)