Cargando…

Empagliflozin Reduces Renal Hyperfiltration in Response to Uninephrectomy, but Is Not Nephroprotective in UNx/DOCA/Salt Mouse Models

Large-scale clinical outcome studies demonstrated the efficacy of SGLT2 inhibitors in patients with type II diabetes. Besides their therapeutic efficacy in diabetes, significant renoprotection was observed in non-diabetic patients with chronic kidney disease (CKD), suggesting the existence of glucos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tauber, Philipp, Sinha, Frederick, Berger, Raffaela S., Gronwald, Wolfram, Dettmer, Katja, Kuhn, Michaela, Trum, Maximilian, Maier, Lars S., Wagner, Stefan, Schweda, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724563/ https://www.ncbi.nlm.nih.gov/pubmed/34992532 http://dx.doi.org/10.3389/fphar.2021.761855

Ejemplares similares

Altered Regulation of Renal Sodium Transporters in Salt-Sensitive Hypertensive Rats Induced by Uninephrectomy
por: Jung, Ji Yong, et al.
Publicado: (2009)

Mycophenolate Mofetil Attenuates DOCA-Salt Hypertension: Effects on Vascular Tone
por: Moes, Arthur D., et al.
Publicado: (2018)

Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats
por: Wang, Dong, et al.
Publicado: (2017)

Genetic Abrogation of Adenosine A(3) Receptor Prevents Uninephrectomy and High Salt–Induced Hypertension
por: Yang, Ting, et al.
Publicado: (2016)

Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice
por: Sembach, Frederikke E., et al.
Publicado: (2019)

The DOCA-Salt Hypertensive Rat as a Model of Cardiovascular Oxidative and Inflammatory Stress
por: Iyer, Abishek, et al.
Publicado: (2010)

Effects of chronic crocin treatment on desoxycorticosterone acetate (doca)-salt hypertensive rats
por: Imenshahidi, Mohsen, et al.
Publicado: (2014)

Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension
por: Amaral, Jefferson H., et al.
Publicado: (2015)

Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury
por: Song, Kai, et al.
Publicado: (2016)

Evidence for glucocorticoid-mediated hypertension after uninephrectomy
por: Huesler, Carina, et al.
Publicado: (2013)

EFFECTS OF CHRONIC EXCESS SALT INGESTION : ROLE OF GENETIC FACTORS IN BOTH DOCA-SALT AND RENAL HYPERTENSION
por: Dahl, Lewis K., et al.
Publicado: (1963)

α-MSH Analogue Attenuates Blood Pressure Elevation in DOCA-Salt Hypertensive Mice
por: Rinne, Petteri, et al.
Publicado: (2013)

Modulatory effect of sesamol on DOCA-salt-induced oxidative stress in uninephrectomized hypertensive rats
por: Hemalatha, Govindasamy, et al.
Publicado: (2013)

Renoprotective Effect of the Histone Deacetylase Inhibitor CG200745 in DOCA-Salt Hypertensive Rats
por: Bae, Eun Hui, et al.
Publicado: (2019)

Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent
por: Williams, Clintoria R, et al.
Publicado: (2014)

Empagliflozin increases kidney weight due to increased cell size in the proximal tubule S3 segment and the collecting duct
por: Sinha, Frederick, et al.
Publicado: (2023)

Nitrooleic Acid Attenuates Lipid Metabolic Disorders and Liver Steatosis in DOCA-Salt Hypertensive Mice
por: Wang, Haiping, et al.
Publicado: (2015)

PGC-1α overexpression suppresses blood pressure elevation in DOCA-salt hypertensive mice
por: Zhao, Qingbin, et al.
Publicado: (2015)

Evidence of Cardiovascular Calcification and Fibrosis in Pseudoxanthoma Elasticum Mouse Models Subjected to DOCA-Salt Hypertension
por: Omarjee, Loukman, et al.
Publicado: (2019)

Captopril Alleviates Chondrocyte Senescence in DOCA-Salt Hypertensive Rats Associated with Gut Microbiome Alteration
por: Chan, Lok Chun, et al.
Publicado: (2022)

Empagliflozin inhibits Na(+)/H(+) exchanger activity in human atrial cardiomyocytes
por: Trum, Maximilian, et al.
Publicado: (2020)

Interaction of central Angiotensin II and estrogen on systolic blood pressure in female DOCA-salt treated rats
por: Kafami, Marzieh, et al.
Publicado: (2016)

Mycophenolate Improves Brain–Gut Axis Inducing Remodeling of Gut Microbiota in DOCA-Salt Hypertensive Rats
por: Robles-Vera, Iñaki, et al.
Publicado: (2020)

Cardiac Natriuretic Peptide Profiles in Chronic Hypertension by Single or Sequentially Combined Renovascular and DOCA-Salt Treatments
por: Cerrudo, Carolina S., et al.
Publicado: (2021)

Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats
por: Robles-Vera, Iñaki, et al.
Publicado: (2021)

Angiopoietins Modulate Endothelial Adaptation, Glomerular and Podocyte Hypertrophy after Uninephrectomy
por: Chiang, Wen Chih, et al.
Publicado: (2013)

Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy
por: Thisted, Louise, et al.
Publicado: (2020)

Effect of Scurrula atropurpurea on nitric oxide, endothelial damage, and endothelial progenitor cells of DOCA-salt hypertensive rats
por: Athiroh, Nour, et al.
Publicado: (2014)

Adipose Mesenchymal Cells-Derived EVs Alleviate DOCA-Salt-Induced Hypertension by Promoting Cardio-Renal Protection
por: Lindoso, Rafael Soares, et al.
Publicado: (2019)

Isotope Ratio Outlier Analysis (IROA) for HPLC–TOFMS-Based Metabolomics of Human Urine
por: Fadil, Fadi, et al.
Publicado: (2022)

Empagliflozin reduces Ca/calmodulin‐dependent kinase II activity in isolated ventricular cardiomyocytes
por: Mustroph, Julian, et al.
Publicado: (2018)

Uninephrectomy-Induced Lipolysis and Low-Grade Inflammation Are Mimicked by Unilateral Renal Denervation
por: Arsenijevic, Denis, et al.
Publicado: (2016)

Activation of the Renal PI3K/Akt/mTOR Signaling Pathway in a DOCA-Salt Model of Hypertension
por: Ma, Seong Kwon, et al.
Publicado: (2012)

Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice
por: Lyu, Bingqing, et al.
Publicado: (2020)

ROS Suppression by Egg White Hydrolysate in DOCA-Salt Rats—An Alternative Tool against Vascular Dysfunction in Severe Hypertension
por: Abreu, Edina da Luz, et al.
Publicado: (2022)

Renal injury after uninephrectomy in male and female intrauterine growth-restricted aged rats
por: Newsome, Ashley D., et al.
Publicado: (2019)

Empagliflozin Inhibits Cardiac Late Sodium Current by Ca/Calmodulin-Dependent Kinase II
por: Mustroph, Julian, et al.
Publicado: (2022)

Arterial expression of 5-HT(2B )and 5-HT(1B )receptors during development of DOCA-salt hypertension
por: Banes, Amy KL, et al.
Publicado: (2003)

Long-Term Inhibition of Xanthine Oxidase by Febuxostat Does Not Decrease Blood Pressure in Deoxycorticosterone Acetate (DOCA)-Salt Hypertensive Rats
por: Szasz, Theodora, et al.
Publicado: (2013)

Myeloid Angiotensin II Type 1 Receptor Mediates Macrophage Polarization and Promotes Vascular Injury in DOCA/Salt Hypertensive Mice
por: Yang, Xue-Feng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n7l7u53det0bubke7gdunomuub