SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages

Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy. Here, we show that ACE2-overexpressing A549 cell-derived microparticles (AO-MPs) are a potential therapeutic agent against SARS-CoV-2 infection. Intranasally administer...

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Detalles Bibliográficos
Autores principales: Wang, Zhenfeng, Lv, Jiadi, Yu, Pin, Qu, Yajin, Zhou, Yabo, Zhou, Li, Zhu, Qiangqiang, Li, Shunshun, Song, Jiangping, Deng, Wei, Gao, Ran, Liu, Yuying, Liu, Jiangning, Tong, Wei-Min, Qin, Chuan, Huang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724656/
https://www.ncbi.nlm.nih.gov/pubmed/34983944
http://dx.doi.org/10.1038/s41423-021-00813-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724656/
https://www.ncbi.nlm.nih.gov/pubmed/34983944
http://dx.doi.org/10.1038/s41423-021-00813-6

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