C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation

Intronic GGGGCC (G4C2) hexanucleotide repeat expansion within the human C9orf72 gene represents the most common cause of familial forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS/FTD). Repeat‐associated non‐AUG (RAN) translation of repeat‐containing C9orf72 RNA r...

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Detalles Bibliográficos
Autores principales: Licata, Nausicaa V, Cristofani, Riccardo, Salomonsson, Sally, Wilson, Katherine M, Kempthorne, Liam, Vaizoglu, Deniz, D’Agostino, Vito G, Pollini, Daniele, Loffredo, Rosa, Pancher, Michael, Adami, Valentina, Bellosta, Paola, Ratti, Antonia, Viero, Gabriella, Quattrone, Alessandro, Isaacs, Adrian M, Poletti, Angelo, Provenzani, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724771/
https://www.ncbi.nlm.nih.gov/pubmed/34791698
http://dx.doi.org/10.15252/embj.2020105026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724771/
https://www.ncbi.nlm.nih.gov/pubmed/34791698
http://dx.doi.org/10.15252/embj.2020105026

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