Lacosamide Inhibition of Na(V)1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore

Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium channels, lacosamide enhances slow-inactivation of these channels, suggesting different bi...

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Detalles Bibliográficos
Autores principales: Labau, Julie I. R., Alsaloum, Matthew, Estacion, Mark, Tanaka, Brian, Dib-Hajj, Fadia B., Lauria, Giuseppe, Smeets, Hubert J. M., Faber, Catharina G., Dib-Hajj, Sulayman, Waxman, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724789/
https://www.ncbi.nlm.nih.gov/pubmed/34992539
http://dx.doi.org/10.3389/fphar.2021.791740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724789/
https://www.ncbi.nlm.nih.gov/pubmed/34992539
http://dx.doi.org/10.3389/fphar.2021.791740

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