Novel GPR43 Agonists Exert an Anti-Inflammatory Effect in a Colitis Model

GPR43 (also known as FFAR2), a metabolite-sensing G-protein-coupled receptor stimulated by short-chain fatty acid (SCFA) ligands is involved in innate immunity and metabolism. GPR43 couples with Gα(i/o) and Gα(q/11) heterotrimeric proteins and is capable of decreasing cyclic AMP and inducing Ca(2+)...

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Detalles Bibliográficos
Autores principales: Park, Bi-Oh, Kang, Jong Soon, Paudel, Suresh, Park, Sung Goo, Park, Byoung Chul, Han, Sang-Bae, Kwak, Young-Shin, Kim, Jeong-Hoon, Kim, Sunhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724840/
https://www.ncbi.nlm.nih.gov/pubmed/34168098
http://dx.doi.org/10.4062/biomolther.2021.078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724840/
https://www.ncbi.nlm.nih.gov/pubmed/34168098
http://dx.doi.org/10.4062/biomolther.2021.078

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