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Novel GPR43 Agonists Exert an Anti-Inflammatory Effect in a Colitis Model
GPR43 (also known as FFAR2), a metabolite-sensing G-protein-coupled receptor stimulated by short-chain fatty acid (SCFA) ligands is involved in innate immunity and metabolism. GPR43 couples with Gα(i/o) and Gα(q/11) heterotrimeric proteins and is capable of decreasing cyclic AMP and inducing Ca(2+)...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Korean Society of Applied Pharmacology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724840/ https://www.ncbi.nlm.nih.gov/pubmed/34168098 http://dx.doi.org/10.4062/biomolther.2021.078 |