Rationally designed foldameric adjuvants enhance antibiotic efficacy via promoting membrane hyperpolarization

The negative membrane potential of bacterial cells influences crucial cellular processes. Inspired by the molecular scaffold of the antimicrobial peptide PGLa, we have developed antimicrobial foldamers with a computer-guided design strategy. The novel PGLa analogues induce sustained membrane hyperpo...

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Detalles Bibliográficos
Autores principales: Bhaumik, Kaushik Nath, Hetényi, Anasztázia, Olajos, Gábor, Martins, Ana, Spohn, Réka, Németh, Lukács, Jojart, Balázs, Szili, Petra, Dunai, Anett, Jangir, Pramod K., Daruka, Lejla, Földesi, Imre, Kata, Diána, Pál, Csaba, Martinek, Tamás A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724909/
https://www.ncbi.nlm.nih.gov/pubmed/35127141
http://dx.doi.org/10.1039/d1me00118c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724909/
https://www.ncbi.nlm.nih.gov/pubmed/35127141
http://dx.doi.org/10.1039/d1me00118c

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