The effect of mAb and excipient cryoconcentration on long-term frozen storage stability – part 2: Aggregate formation and oxidation

We examined the impact of monoclonal antibody (mAb) and buffer concentration, mimicking the cryoconcentration found upon freezing in a 2 L bottle, on mAb stability during frozen storage. Upon cryoconcentration, larger protein molecules and small excipient molecules freeze-concentrate differently, re...

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Detalles Bibliográficos
Autores principales: Bluemel, Oliver, Buecheler, Jakob W., Hauptmann, Astrid, Hoelzl, Georg, Bechtold-Peters, Karoline, Friess, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724956/
https://www.ncbi.nlm.nih.gov/pubmed/35024604
http://dx.doi.org/10.1016/j.ijpx.2021.100109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724956/
https://www.ncbi.nlm.nih.gov/pubmed/35024604
http://dx.doi.org/10.1016/j.ijpx.2021.100109

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