Identification and characterization of two drug-like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA

Disulfide-bond-forming proteins (Dsbs) play a crucial role in the pathogenicity of many Gram-negative bacteria. Disulfide-bond-forming protein A (DsbA) catalyzes the formation of the disulfide bonds necessary for the activity and stability of multiple substrate proteins, including many virulence fac...

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Detalles Bibliográficos
Autores principales: Petit, Guillaume A., Mohanty, Biswaranjan, McMahon, Róisín M., Nebl, Stefan, Hilko, David H., Wilde, Karyn L., Scanlon, Martin J., Martin, Jennifer L., Halili, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2022
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725163/
https://www.ncbi.nlm.nih.gov/pubmed/34981764
http://dx.doi.org/10.1107/S2059798321011475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725163/
https://www.ncbi.nlm.nih.gov/pubmed/34981764
http://dx.doi.org/10.1107/S2059798321011475

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