Nano delivery of simvastatin targets liver sinusoidal endothelial cells to remodel tumor microenvironment for hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) developed in fibrotic liver does not respond well to immunotherapy, mainly due to the stromal microenvironment and the fibrosis-related immunosuppressive factors. The characteristic of liver sinusoidal endothelial cells (LSECs) in contributing to fibrosis a...

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Detalles Bibliográficos
Autores principales: Yu, Zhuo, Guo, Jianfeng, Liu, Yun, Wang, Menglin, Liu, Zhengsheng, Gao, Yueqiu, Huang, Leaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725360/
https://www.ncbi.nlm.nih.gov/pubmed/34983554
http://dx.doi.org/10.1186/s12951-021-01205-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725360/
https://www.ncbi.nlm.nih.gov/pubmed/34983554
http://dx.doi.org/10.1186/s12951-021-01205-8

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