Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome

OBJECTIVE: Cannabigerolic acid (CBGA), a precursor cannabinoid in Cannabis sativa, has recently been found to have anticonvulsant properties in the Scn1a(+/-) mouse model of Dravet syndrome. Poor brain penetration and chemical instability of CBGA limits its potential as an anticonvulsant therapy. He...

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Detalles Bibliográficos
Autores principales: Anderson, Lyndsey L., Udoh, Michael, Everett-Morgan, Declan, Heblinski, Marika, McGregor, Iain S., Banister, Samuel D., Arnold, Jonathon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725448/
https://www.ncbi.nlm.nih.gov/pubmed/34980287
http://dx.doi.org/10.1186/s42238-021-00113-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725448/
https://www.ncbi.nlm.nih.gov/pubmed/34980287
http://dx.doi.org/10.1186/s42238-021-00113-w

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