Cargando…

Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome

OBJECTIVE: Cannabigerolic acid (CBGA), a precursor cannabinoid in Cannabis sativa, has recently been found to have anticonvulsant properties in the Scn1a(+/-) mouse model of Dravet syndrome. Poor brain penetration and chemical instability of CBGA limits its potential as an anticonvulsant therapy. He...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anderson, Lyndsey L., Udoh, Michael, Everett-Morgan, Declan, Heblinski, Marika, McGregor, Iain S., Banister, Samuel D., Arnold, Jonathon C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725448/ https://www.ncbi.nlm.nih.gov/pubmed/34980287 http://dx.doi.org/10.1186/s42238-021-00113-w

Ejemplares similares

The anticonvulsant phytocannabinoids CBGVA and CBDVA inhibit recombinant T-type channels
por: Udoh, Michael, et al.
Publicado: (2022)

Biosynthesis of cannabinoid precursor olivetolic acid in genetically engineered Yarrowia lipolytica
por: Ma, Jingbo, et al.
Publicado: (2022)

CBGA ameliorates inflammation and fibrosis in nephropathy
por: Suzuki, Sayuri, et al.
Publicado: (2023)

Scale-up of an amoeba-based process for the production of the cannabinoid precursor olivetolic acid
por: Kufs, Johann E., et al.
Publicado: (2022)

Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a(+/)(-) mouse model of Dravet syndrome
por: Anderson, Lyndsey L., et al.
Publicado: (2023)

Ictal vocalizations in the Scn1a (+/−) mouse model of Dravet syndrome
por: Anderson, Lyndsey L., et al.
Publicado: (2023)

Author Correction: Biosynthesis of cannabinoid precursor olivetolic acid in genetically engineered Yarrowia lipolytica
por: Ma, Jingbo, et al.
Publicado: (2022)

The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a (+/−) Mouse Model of Dravet Syndrome
por: Satpute Janve, Vaishali, et al.
Publicado: (2021)

Novel insights into the antibacterial activities of cannabinoid biosynthetic intermediate, olivetolic acid, and its alkyl-chain derivatives
por: Lee, Yuan-E, et al.
Publicado: (2022)

Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Actions of Phytocannabinoids or Endocannabinoids on TRPA1 and TRPV1 Channels
por: Heblinski, Marika, et al.
Publicado: (2020)

Structure of the Cannabis sativa olivetol‐producing enzyme reveals cyclization plasticity in type III polyketide synthases
por: Kearsey, Lewis J., et al.
Publicado: (2019)

Affinity comparison of different THCA synthase to CBGA using modeling computational approaches
por: Alaoui, Moulay Abdelaziz El, et al.
Publicado: (2014)

A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function
por: Milligan, Carol J., et al.
Publicado: (2022)

MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy
por: Harman, Thomas, et al.
Publicado: (2023)

CUMYL-4CN-BINACA Is an Efficacious and Potent Pro-Convulsant Synthetic Cannabinoid Receptor Agonist
por: Kevin, Richard C., et al.
Publicado: (2019)

Evaluation of the Possible Anticonvulsant Effect of Δ(9)-Tetrahydrocannabinolic Acid in Murine Seizure Models
por: Benson, Melissa J., et al.
Publicado: (2022)

Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model
por: Griffin, Aliesha, et al.
Publicado: (2020)

Crystal structure of olivetolic acid: a natural product from Cetrelia sanguinea (Schaer.)
por: Ismed, Friardi, et al.
Publicado: (2016)

Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments
por: Satta, Valentina, et al.
Publicado: (2021)

Off-target pharmacological profiling of synthetic cannabinoid receptor agonists including AMB-FUBINACA, CUMYL-PINACA, PB-22, and XLR-11
por: Kevin, Richard C., et al.
Publicado: (2022)

Anti-obesity effects of olivetol in adult zebrafish model induced by short-term high-fat diet
por: Reshma, Andukuri, et al.
Publicado: (2023)

An Examination of the Anti-Cancer Properties of Plant Cannabinoids in Preclinical Models of Mesothelioma
por: Colvin, Emily K., et al.
Publicado: (2022)

Dravet syndrome
por: Incorpora, Gemma
Publicado: (2009)

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome
por: Anderson, Lyndsey L., et al.
Publicado: (2017)

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB(2) receptor
por: Patel, Monica, et al.
Publicado: (2023)

Vaccinations and Dravet Syndrome
por: Korff, Christian M.
Publicado: (2015)

Phenotypes of Dravet Syndrome
por: Garcia-Sosa, Rebecca, et al.
Publicado: (2016)

Dravet Syndrome: An Overview
por: Anwar, Arsalan, et al.
Publicado: (2019)

Stiripentol for Dravet syndrome
Publicado: (2020)

Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy
por: Anderson, Lyndsey L., et al.
Publicado: (2021)

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy
por: Hawkins, Nicole A., et al.
Publicado: (2017)

Crouch Gait in Dravet Syndrome
por: Black, Laura, et al.
Publicado: (2016)

Anesthetic considerations in Dravet syndrome
por: Macdonald‐Laurs, Emma, et al.
Publicado: (2022)

Open the Window for the Cure of Dravet
por: Gu, Bin
Publicado: (2022)

Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity
por: LaVigne, Justin E., et al.
Publicado: (2021)

Non-Cannabinoid Metabolites of Cannabis sativa L. with Therapeutic Potential
por: Lowe, Henry, et al.
Publicado: (2021)

Research Progress on Cannabinoids in Cannabis (Cannabis sativa L.) in China
por: Sun, Xiangping
Publicado: (2023)

ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice
por: Brzozowska, Natalia, et al.
Publicado: (2016)

Do All Roads Lead to Rome? Genes Causing Dravet Syndrome and Dravet Syndrome-Like Phenotypes
por: Ding, Jiangwei, et al.
Publicado: (2022)

Modulation of type 1 cannabinoid receptor activity by cannabinoid by-products from Cannabis sativa and non-cannabis phytomolecules
por: Zagzoog, Ayat, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qohhquo5pfjacdsh6ml7c809cp