Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

OBJECTIVE: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Histone lysine-specific demethylase 1 (LSD1) is a flavin-containing amino oxidase that can repress or activate transcription. The aim of this study is to explore the mechanism of LSD1 aggravating DN-induced renal f...

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Detalles Bibliográficos
Autores principales: Dong, Lina, Yu, Lei, Zhong, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725532/
https://www.ncbi.nlm.nih.gov/pubmed/34983623
http://dx.doi.org/10.1186/s13098-021-00771-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725532/
https://www.ncbi.nlm.nih.gov/pubmed/34983623
http://dx.doi.org/10.1186/s13098-021-00771-z

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