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Development of a Spontaneous HPV16 E6/E7-Expressing Head and Neck Squamous Cell Carcinoma in HLA-A2 Transgenic Mice

Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is a growing global health problem. HPV16 has been attributed to a majority of HPV-associated HNSCCs. In order to test candidate immunotherapies, we developed a spontaneous HPV16-driven HNSCC model in HLA-A2 (AAD) tr...

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Detalles Bibliográficos
Autores principales: Peng, Shiwen, Xing, Deyin, Ferrall, Louise, Tsai, Ya-Chea, Roden, Richard B. S., Hung, Chien-Fu, Wu, T.-C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725581/
https://www.ncbi.nlm.nih.gov/pubmed/35089069
http://dx.doi.org/10.1128/mbio.03252-21