New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies

A new series of benzoxazole derivatives were designed and synthesised to have the main essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were evaluated for all derivatives against two human cancer cell lines, MCF-7 and HepG2. Also, the effect of the most cytotoxic derivat...

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Detalles Bibliográficos
Autores principales: Elkady, Hazem, Elwan, Alaa, El-Mahdy, Hesham A., Doghish, Ahmed S., Ismail, Ahmed, Taghour, Mohammed S., Elkaeed, Eslam B., Eissa, Ibrahim H., Dahab, Mohammed A., Mahdy, Hazem A., Khalifa, Mohamed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725875/
https://www.ncbi.nlm.nih.gov/pubmed/34961427
http://dx.doi.org/10.1080/14756366.2021.2015343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725875/
https://www.ncbi.nlm.nih.gov/pubmed/34961427
http://dx.doi.org/10.1080/14756366.2021.2015343

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