The Linkage Phase of the Polymorphism KCNH2-K897T Influences the Electrophysiological Phenotype in hiPSC Models of LQT2

While rare mutations in ion channel genes are primarily responsible for inherited cardiac arrhythmias, common genetic variants are also an important contributor to the clinical heterogeneity observed among mutation carriers. The common single nucleotide polymorphism (SNP) KCNH2-K897T is associated w...

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Detalles Bibliográficos
Autores principales: van den Brink, Lettine, Brandão, Karina O., Yiangou, Loukia, Blanch-Asensio, Albert, Mol, Mervyn P. H., Mummery, Christine L., Verkerk, Arie O., Davis, Richard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726482/
https://www.ncbi.nlm.nih.gov/pubmed/34992545
http://dx.doi.org/10.3389/fphys.2021.755642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726482/
https://www.ncbi.nlm.nih.gov/pubmed/34992545
http://dx.doi.org/10.3389/fphys.2021.755642

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