Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo

The five-year survival rate for pancreatic ductal adenocarcinoma (PDAC) has remained a dismal 9% for approximately 40 years with an urgent need for novel therapeutic interventions. ONC201 is the founding member of the imipridone class, comprised of orally bioavailable small molecules that have shown...

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Detalles Bibliográficos
Autores principales: Jhaveri, Aakash V., Zhou, Lanlan, Ralff, Marie D., Lee, Young S., Navaraj, Arunasalam, Carneiro, Benedito A., Safran, Howard, Prabhu, Varun V., Ross, Eric A., Lee, Seulki, El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726623/
https://www.ncbi.nlm.nih.gov/pubmed/34856854
http://dx.doi.org/10.1080/15384047.2021.1976567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726623/
https://www.ncbi.nlm.nih.gov/pubmed/34856854
http://dx.doi.org/10.1080/15384047.2021.1976567

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