The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance

The occurrence of an immune response against therapeutic proteins poses a major risk for the development of biologics and for successful treatment of patients. Generation of anti-drug antibodies (ADAs) can lead to formation of immune complexes (ICs), consisting of drug and ADAs, with potential impac...

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Detalles Bibliográficos
Autores principales: Opolka-Hoffmann, Eugenia, Jordan, Gregor, Otteneder, Michael, Kieferle, Robin, Lechmann, Martin, Winter, Gerhard, Staack, Roland F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726625/
https://www.ncbi.nlm.nih.gov/pubmed/34763611
http://dx.doi.org/10.1080/19420862.2021.1995929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726625/
https://www.ncbi.nlm.nih.gov/pubmed/34763611
http://dx.doi.org/10.1080/19420862.2021.1995929

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