Antitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo

ONC201 demonstrated promising activity in patients with advanced endometrial cancer in a Phase I clinical trial. ONC201 activates the integrated stress response (ISR) and upregulates TRAIL and its receptor DR5. We hypothesized ONC201 upregulation of DR5 could sensitize tumors to TRAIL and combinatio...

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Detalles Bibliográficos
Autores principales: Ray, Jocelyn E., Ralff, Marie D., Jhaveri, Aakash, Zhou, Lanlan, Dicker, David T., Ross, Eric A., El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726732/
https://www.ncbi.nlm.nih.gov/pubmed/34696710
http://dx.doi.org/10.1080/15384047.2021.1977067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726732/
https://www.ncbi.nlm.nih.gov/pubmed/34696710
http://dx.doi.org/10.1080/15384047.2021.1977067

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