Src activates retrograde membrane traffic through phosphorylation of GBF1

The Src tyrosine kinase controls cancer-critical protein glycosylation through Golgi to ER relocation of GALNTs enzymes. How Src induces this trafficking event is unknown. Golgi to ER transport depends on the GTP exchange factor (GEF) GBF1 and small GTPase Arf1. Here, we show that Src induces the fo...

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Detalles Bibliográficos
Autores principales: Chia, Joanne, Wang, Shyi-Chyi, Wee, Sheena, Gill, David James, Tay, Felicia, Kannan, Srinivasaraghavan, Verma, Chandra S, Gunaratne, Jayantha, Bard, Frederic A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727025/
https://www.ncbi.nlm.nih.gov/pubmed/34870592
http://dx.doi.org/10.7554/eLife.68678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727025/
https://www.ncbi.nlm.nih.gov/pubmed/34870592
http://dx.doi.org/10.7554/eLife.68678

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