Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans

Monoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with CLL risk among individuals of European...

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Detalles Bibliográficos
Autores principales: Kleinstern, Geffen, Weinberg, J. Brice, Parikh, Sameer A., Braggio, Esteban, Achenbach, Sara J., Robinson, Dennis P., Norman, Aaron D., Rabe, Kari G., Boddicker, Nicholas J., Vachon, Celine M., Lesnick, Connie E., Call, Timothy G., Brander, Danielle M., Rassenti, Laura Z., Kipps, Thomas J., Olson, Janet E., Cerhan, James R., Kay, Neil E., Furman, Richard R., Hanson, Curtis A., Shanafelt, Tait D., Slager, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727288/
https://www.ncbi.nlm.nih.gov/pubmed/34285341
http://dx.doi.org/10.1038/s41375-021-01344-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727288/
https://www.ncbi.nlm.nih.gov/pubmed/34285341
http://dx.doi.org/10.1038/s41375-021-01344-9

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