Therapeutic Effect of Novel Cyanopyrrolidine-Based Prolyl Oligopeptidase Inhibitors in Rat Models of Amnesia

Prolyl oligopeptidase (POP) is a large cytosolic serine peptidase that is altered in patients with Alzheimer’s disease, Parkinsonian syndrome, muscular dystrophies, and other denervating diseases. Thus, POP may represent a relevant therapeutic target for treatment of neuropsychiatric disorders and n...

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Detalles Bibliográficos
Autores principales: Zolotov, Nikolay N., Schepetkin, Igor A., Voronina, Tatyana A., Pozdnev, Vladimir F., Khlebnikov, Andrei I., Krylova, Irina V., Quinn, Mark T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727363/
https://www.ncbi.nlm.nih.gov/pubmed/35004610
http://dx.doi.org/10.3389/fchem.2021.780958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727363/
https://www.ncbi.nlm.nih.gov/pubmed/35004610
http://dx.doi.org/10.3389/fchem.2021.780958

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