Targeting Proteinase Activated Receptor-4 Reduces Mechanonociception During the Acute Inflammatory Phase but not the Chronic Neuropathic Phase of Osteoarthritis in Rats

Serine proteases are elevated in arthritic joints where they can cleave protease activated receptors (PARs) to modulate pain and inflammation. Activation of protease-activated receptor 4 (PAR4) has been implicated in inflammatory joint pain. Whether PAR4 is involved in osteoarthritis (OA) pain has n...

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Detalles Bibliográficos
Autores principales: O’Brien, Melissa S., McDougall, Jason J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727523/
https://www.ncbi.nlm.nih.gov/pubmed/35002698
http://dx.doi.org/10.3389/fphar.2021.756632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727523/
https://www.ncbi.nlm.nih.gov/pubmed/35002698
http://dx.doi.org/10.3389/fphar.2021.756632

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