Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations
In the United States, the number of people suffering from opioid use disorder has skyrocketed in all populations. Nevertheless, observations of racial disparities amongst opioid overdose deaths have recently been described. Opioid use disorder is characterized by compulsive drug consumption followed...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727544/ https://www.ncbi.nlm.nih.gov/pubmed/35002733 http://dx.doi.org/10.3389/fphar.2021.798362 |
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author | Blackwood, Christopher A. Cadet, Jean Lud |
author_facet | Blackwood, Christopher A. Cadet, Jean Lud |
author_sort | Blackwood, Christopher A. |
collection | PubMed |
description | In the United States, the number of people suffering from opioid use disorder has skyrocketed in all populations. Nevertheless, observations of racial disparities amongst opioid overdose deaths have recently been described. Opioid use disorder is characterized by compulsive drug consumption followed by periods of withdrawal and recurrent relapses while patients are participating in treatment programs. Similar to other rewarding substances, exposure to opioid drugs is accompanied by epigenetic changes in the brain. In addition, genetic factors that are understudied in some racial groups may also impact the clinical manifestations of opioid use disorder. These studies are important because genetic factors and epigenetic alterations may also influence responses to pharmacological therapeutic approaches. Thus, this mini-review seeks to briefly summarize what is known about the genetic bases of opioid use disorder in African Americans. |
format | Online Article Text |
id | pubmed-8727544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87275442022-01-06 Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations Blackwood, Christopher A. Cadet, Jean Lud Front Pharmacol Pharmacology In the United States, the number of people suffering from opioid use disorder has skyrocketed in all populations. Nevertheless, observations of racial disparities amongst opioid overdose deaths have recently been described. Opioid use disorder is characterized by compulsive drug consumption followed by periods of withdrawal and recurrent relapses while patients are participating in treatment programs. Similar to other rewarding substances, exposure to opioid drugs is accompanied by epigenetic changes in the brain. In addition, genetic factors that are understudied in some racial groups may also impact the clinical manifestations of opioid use disorder. These studies are important because genetic factors and epigenetic alterations may also influence responses to pharmacological therapeutic approaches. Thus, this mini-review seeks to briefly summarize what is known about the genetic bases of opioid use disorder in African Americans. Frontiers Media S.A. 2021-12-22 /pmc/articles/PMC8727544/ /pubmed/35002733 http://dx.doi.org/10.3389/fphar.2021.798362 Text en Copyright © 2021 Blackwood and Cadet. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Blackwood, Christopher A. Cadet, Jean Lud Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations |
title | Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations |
title_full | Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations |
title_fullStr | Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations |
title_full_unstemmed | Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations |
title_short | Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations |
title_sort | epigenetic and genetic factors associated with opioid use disorder: are these relevant to african american populations |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727544/ https://www.ncbi.nlm.nih.gov/pubmed/35002733 http://dx.doi.org/10.3389/fphar.2021.798362 |
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