Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations

In the United States, the number of people suffering from opioid use disorder has skyrocketed in all populations. Nevertheless, observations of racial disparities amongst opioid overdose deaths have recently been described. Opioid use disorder is characterized by compulsive drug consumption followed...

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Autores principales: Blackwood, Christopher A., Cadet, Jean Lud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727544/
https://www.ncbi.nlm.nih.gov/pubmed/35002733
http://dx.doi.org/10.3389/fphar.2021.798362
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author Blackwood, Christopher A.
Cadet, Jean Lud
author_facet Blackwood, Christopher A.
Cadet, Jean Lud
author_sort Blackwood, Christopher A.
collection PubMed
description In the United States, the number of people suffering from opioid use disorder has skyrocketed in all populations. Nevertheless, observations of racial disparities amongst opioid overdose deaths have recently been described. Opioid use disorder is characterized by compulsive drug consumption followed by periods of withdrawal and recurrent relapses while patients are participating in treatment programs. Similar to other rewarding substances, exposure to opioid drugs is accompanied by epigenetic changes in the brain. In addition, genetic factors that are understudied in some racial groups may also impact the clinical manifestations of opioid use disorder. These studies are important because genetic factors and epigenetic alterations may also influence responses to pharmacological therapeutic approaches. Thus, this mini-review seeks to briefly summarize what is known about the genetic bases of opioid use disorder in African Americans.
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spelling pubmed-87275442022-01-06 Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations Blackwood, Christopher A. Cadet, Jean Lud Front Pharmacol Pharmacology In the United States, the number of people suffering from opioid use disorder has skyrocketed in all populations. Nevertheless, observations of racial disparities amongst opioid overdose deaths have recently been described. Opioid use disorder is characterized by compulsive drug consumption followed by periods of withdrawal and recurrent relapses while patients are participating in treatment programs. Similar to other rewarding substances, exposure to opioid drugs is accompanied by epigenetic changes in the brain. In addition, genetic factors that are understudied in some racial groups may also impact the clinical manifestations of opioid use disorder. These studies are important because genetic factors and epigenetic alterations may also influence responses to pharmacological therapeutic approaches. Thus, this mini-review seeks to briefly summarize what is known about the genetic bases of opioid use disorder in African Americans. Frontiers Media S.A. 2021-12-22 /pmc/articles/PMC8727544/ /pubmed/35002733 http://dx.doi.org/10.3389/fphar.2021.798362 Text en Copyright © 2021 Blackwood and Cadet. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Blackwood, Christopher A.
Cadet, Jean Lud
Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations
title Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations
title_full Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations
title_fullStr Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations
title_full_unstemmed Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations
title_short Epigenetic and Genetic Factors Associated With Opioid Use Disorder: Are These Relevant to African American Populations
title_sort epigenetic and genetic factors associated with opioid use disorder: are these relevant to african american populations
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727544/
https://www.ncbi.nlm.nih.gov/pubmed/35002733
http://dx.doi.org/10.3389/fphar.2021.798362
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