Inhibition of Brain GTP Cyclohydrolase I Attenuates 3-Nitropropionic Acid-Induced Striatal Toxicity: Involvement of Mas Receptor/PI3k/Akt/CREB/ BDNF Axis

GTP cyclohydrolase I (GTPCH I) is the rate-limiting enzyme for tetrahydrobiopterin (BH4) biosynthesis; the latter is an essential factor for iNOS activation that contributes neuronal loss in Huntington’s disease (HD). The aim of the study was to investigate the neuroprotective effect of 2,4-diamino-...

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Detalles Bibliográficos
Autores principales: Mustafa, Aya M., Rabie, Mostafa A., Zaki, Hala F., Shaheen, Aya M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727546/
https://www.ncbi.nlm.nih.gov/pubmed/35002694
http://dx.doi.org/10.3389/fphar.2021.740966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727546/
https://www.ncbi.nlm.nih.gov/pubmed/35002694
http://dx.doi.org/10.3389/fphar.2021.740966

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