Cargando…

Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

The intervertebral disc (IVD) is the largest avascular tissue. Hypoxia-inducible factors (HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease (DDD) is one of the leading causes of disability, and current therapies are inef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zuqiang, Chen, Hangang, Tan, Qiaoyan, Huang, Junlan, Zhou, Siru, Luo, Fengtao, Zhang, Dali, Yang, Jing, Li, Can, Chen, Bo, Sun, Xianding, Kuang, Liang, Jiang, Wanling, Ni, Zhenhong, Wang, Quan, Chen, Shuai, Du, Xiaolan, Chen, Di, Deng, Chuxia, Yin, Liangjun, Chen, Lin, Xie, Yangli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727577/ https://www.ncbi.nlm.nih.gov/pubmed/34983922 http://dx.doi.org/10.1038/s41413-021-00165-x

Ejemplares similares

Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model
por: Luo, Fengtao, et al.
Publicado: (2018)

Exogenous Indian hedgehog antagonist damages intervertebral discs homeostasis in adult mice
por: Chen, Ran, et al.
Publicado: (2022)

FGFR3 deficient mice have accelerated fracture repair
por: Xie, Yangli, et al.
Publicado: (2017)

Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway
por: Sun, Xianding, et al.
Publicado: (2020)

Long term usage of dexamethasone accelerating the initiation of osteoarthritis via enhancing the extracellular matrix calcification and apoptosis of chondrocytes
por: Chen, Liang, et al.
Publicado: (2021)

Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL‐1β/NF‐κB pathway
por: Wang, Zuqiang, et al.
Publicado: (2017)

Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway
por: Zhang, Dali, et al.
Publicado: (2021)

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration
por: Xu, Meng, et al.
Publicado: (2022)

A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis
por: Tan, Qiaoyan, et al.
Publicado: (2018)

Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice
por: Zhou, Siru, et al.
Publicado: (2016)

Imbalanced development of anterior and posterior thorax is a causative factor triggering scoliosis
por: Chen, Bo, et al.
Publicado: (2019)

FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling
por: Zhou, Siru, et al.
Publicado: (2015)

PTH 1-34 Ameliorates the Osteopenia and Delayed Healing of Stabilized Tibia Fracture in Mice with Achondroplasia Resulting from Gain-Of-Function Mutation of FGFR3
por: Chen, Hangang, et al.
Publicado: (2017)

Deformed Skull Morphology Is Caused by the Combined Effects of the Maldevelopment of Calvarias, Cranial Base and Brain in FGFR2-P253R Mice Mimicking Human Apert Syndrome
por: Luo, Fengtao, et al.
Publicado: (2017)

FGF/FGFR signaling in health and disease
por: Xie, Yangli, et al.
Publicado: (2020)

Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling
por: Sun, Xianding, et al.
Publicado: (2020)

The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis
por: Ni, Zhenhong, et al.
Publicado: (2019)

A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis
por: Xu, Wei, et al.
Publicado: (2016)

Fibroblast Growth Factor Receptor 3 Deficiency Does Not Impair the Osteoanabolic Action of Parathyroid Hormone on Mice
por: Xie, Yangli, et al.
Publicado: (2016)

Exosomes: roles and therapeutic potential in osteoarthritis
por: Ni, Zhenhong, et al.
Publicado: (2020)

Pulsed Electromagnetic Field Inhibits Synovitis via Enhancing the Efferocytosis of Macrophages
por: Ouyang, Junjie, et al.
Publicado: (2020)

Association rules analysis on patterns of multimorbidity in adults: based on the National Health and Nutrition Examination Surveys database
por: Zheng, Zheng, et al.
Publicado: (2022)

Mechanotransduction in intervertebral discs
por: Tsai, Tsung-Ting, et al.
Publicado: (2014)

Bone function, dysfunction and its role in diseases including critical illness
por: Su, Nan, et al.
Publicado: (2019)

Annular Defects Impair the Mechanical Stability of the Intervertebral Disc
por: Chen, Jun-Xin, et al.
Publicado: (2021)

Fabrication of a novel whole tissue-engineered intervertebral disc for intervertebral disc regeneration in the porcine lumbar spine
por: Yang, Fei, et al.
Publicado: (2018)

The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe?
por: Li, Yongjin, et al.
Publicado: (2021)

The intervertebral disc /
por: De Palma, Anthony F.
Publicado: (1970)

Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: a microarray related study
por: Wan, Zhong-Yuan, et al.
Publicado: (2014)

Species variation in the cartilaginous endplate of the lumbar intervertebral disc
por: Li, Yun‐He, et al.
Publicado: (2022)

Intervertebral Disc Progenitors: Lessons Learned from Single-Cell RNA Sequencing and the Role in Intervertebral Disc Regeneration
por: Zhao, Yu-Dong, et al.
Publicado: (2023)

Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth
por: Fu, Fangda, et al.
Publicado: (2021)

Decellularized allogeneic intervertebral disc: natural biomaterials for regenerating disc degeneration
por: Lin, Xianfeng, et al.
Publicado: (2016)

Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications
por: Lappalainen, Anu K, et al.
Publicado: (2014)

The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment
por: Sun, Zhen, et al.
Publicado: (2020)

Intervertebral Disc Nucleus Repair: Hype or Hope?
por: Tendulkar, Gauri, et al.
Publicado: (2019)

Construction and assessment of bio-engineered intervertebral discs
por: Xiang, Hongfei, et al.
Publicado: (2017)

Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc
por: Yan, Caiping, et al.
Publicado: (2021)

Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1
por: Liu, Chenhao, et al.
Publicado: (2023)

Degeneration of the intervertebral disc
por: Urban, Jill PG, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_k79fguopc64fhk10cigk4evqcc