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A multivariate modeling framework to quantify immune checkpoint context-dependent stimulation on T cells
Cells receive, and adjust to, various stimuli, which function as part of complex microenvironments forming their “context”. The possibility that a given context impacts the response to a given stimulus defines “context-dependency” and it explains large parts of the functional variability of physiopa...
Autores principales: | Karpf, Léa, Trichot, Coline, Faucheux, Lilith, Legbre, Iris, Grandclaudon, Maximilien, Lahoute, Charlotte, Mattoo, Hamid, Pasquier, Benoit, Soumelis, Vassili |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727669/ https://www.ncbi.nlm.nih.gov/pubmed/34983927 http://dx.doi.org/10.1038/s41421-021-00352-4 |
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