Cargando…

A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease

Insurmountable blood‒brain barrier (BBB) and complex pathological features are the key factors affecting the treatment of Alzheimer's disease (AD). Poor accumulation of drugs in lesion sites and undesired effectiveness of simply reducing Aβ deposition or TAU protein need to be resolved urgently...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lei, Ting, Yang, Zhihang, Xia, Xue, Chen, Yuxiu, Yang, Xiaotong, Xie, Rou, Tong, Fan, Wang, Xiaolin, Gao, Huile
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727781/ https://www.ncbi.nlm.nih.gov/pubmed/35024324 http://dx.doi.org/10.1016/j.apsb.2021.04.022

Ejemplares similares

Author correction to “A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer’s disease” [Acta Pharmaceutica Sinica B 12, (2021) 4032–4044]
por: Lei, Ting, et al.
Publicado: (2022)

GSH-responsive SN38 dimer-loaded shape-transformable nanoparticles with iRGD for enhancing chemo-photodynamic therapy
por: Lin, Congcong, et al.
Publicado: (2020)

Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection
por: He, Xueqin, et al.
Publicado: (2022)

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy
por: Zhou, Yutong, et al.
Publicado: (2020)

Penetration of Water-Soluble Material through Gas-Cleaning Filters
por: Schwarz, Almuth D., et al.
Publicado: (2022)

Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer’s Disease
por: Huang, Qianqian, et al.
Publicado: (2023)

Supramolecular nanomedicines based on host–guest interactions of cyclodextrins
por: Tong, Fan, et al.
Publicado: (2023)

Toxic Effects of Penetrating Cations
por: Sokolov, Svyatoslav, et al.
Publicado: (2023)

Cell Penetrating Peptide Derived from Human Eosinophil Cationic Protein Decreases Airway Allergic Inflammation
por: Fu, Lin-shien, et al.
Publicado: (2017)

Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment
por: Hu, Guanlian, et al.
Publicado: (2015)

Comparison and Avoidance of Toxicity of Penetrating Cryoprotectants
por: Szurek, Edyta A., et al.
Publicado: (2011)

Penetration and Toxicity of Nanomaterials in Higher Plants
por: Chichiriccò, Giuseppe, et al.
Publicado: (2015)

A tumor-to-lymph procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis
por: Qin, Lin, et al.
Publicado: (2020)

Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor‐associated macrophages
por: Tong, Fan, et al.
Publicado: (2023)

Blood–brain barrier penetration prediction enhanced by uncertainty estimation
por: Tong, Xiaochu, et al.
Publicado: (2022)

Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
por: Rofo, Fadi, et al.
Publicado: (2022)

A Nano-Cleaning Fluid for Downhole Casing Cleaning
por: Song, Hanxuan, et al.
Publicado: (2023)

Barriers to cleaning of shared latrines in slums of Addis Ababa, Ethiopia
por: Hailu, Kidist, et al.
Publicado: (2022)

The construction of in vitro nasal cavity-mimic M-cell model, design of M cell-targeting nanoparticles and evaluation of mucosal vaccination by nasal administration
por: Yang, Xiaotong, et al.
Publicado: (2020)

Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors
por: Zhou, Yang, et al.
Publicado: (2022)

Penetration of a two-dimensional fission barrier
por: Szymanski Z, et al.
Publicado: (1970)

Rethinking CRITID Procedure of Brain Targeting Drug Delivery: Circulation, Blood Brain Barrier Recognition, Intracellular Transport, Diseased Cell Targeting, Internalization, and Drug Release
por: Ruan, Shaobo, et al.
Publicado: (2021)

A detachable coating of cholesterol-anchored PEG improves tumor targeting of cell-penetrating peptide-modified liposomes
por: Tang, Jie, et al.
Publicado: (2014)

Clean Home-delivery in Rural Southern Tanzania: Barriers, Influencers, and Facilitators
por: Shamba, Donat D., et al.
Publicado: (2013)

Aseptic Barriers Allow a Clean Contact for Contaminated Stethoscope Diaphragms
por: Vasudevan, Rajiv, et al.
Publicado: (2020)

Dual Receptor Recognizing Cell Penetrating Peptide for Selective Targeting, Efficient Intratumoral Diffusion and Synthesized Anti-Glioma Therapy
por: Liu, Yayuan, et al.
Publicado: (2016)

Stromal barriers to nanomedicine penetration in the pancreatic tumor microenvironment
por: Tanaka, Hiroyoshi Y., et al.
Publicado: (2018)

Modulating intestinal mucus barrier for nanoparticles penetration by surfactants
por: Zhang, Xin, et al.
Publicado: (2019)

To clean or not to clean: Cleaning mutualism breakdown in a tidal environment
por: Dunkley, Katie, et al.
Publicado: (2020)

Pathogenic bacteria exploit transferrin receptor transcytosis to penetrate the blood–brain barrier
por: Cheng, Zhihui, et al.
Publicado: (2023)

Correlating Cleaning Thoroughness with Effectiveness and Briefly Intervening to Affect Cleaning Outcomes: How Clean Is Cleaned?
por: Clifford, Robert, et al.
Publicado: (2016)

BBPpredict: A Web Service for Identifying Blood-Brain Barrier Penetrating Peptides
por: Chen, Xue, et al.
Publicado: (2022)

Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices
por: Rodríguez, Cristian F., et al.
Publicado: (2023)

Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier
por: Liu, Tong-Bao, et al.
Publicado: (2013)

The remineralization effect of GERM CLEAN on early human enamel caries lesions in vitro
por: Wang, Ye, et al.
Publicado: (2023)

Aluminium in the Human Brain: Routes of Penetration, Toxicity, and Resulting Complications
por: Bryliński, Łukasz, et al.
Publicado: (2023)

Penetration of polar organic compounds through the blood-brain barrier
por: Kalász, Huba, et al.
Publicado: (2011)

Quorum Sensing Peptides Selectively Penetrate the Blood-Brain Barrier
por: Wynendaele, Evelien, et al.
Publicado: (2015)

Down-regulation of cyclin D2 in amyloid β toxicity, inflammation, and Alzheimer’s disease
por: Czapski, Grzegorz A., et al.
Publicado: (2021)

The Effects of a Blood–Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy
por: Yang, Joshua, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7dq7efi01eb54eh2rdevb8jr3p