Mutation rate and spectrum in obligately outcrossing Caenorhabditis elegans mutation accumulation lines subjected to RNAi-induced knockdown of the mismatch repair gene msh-2

DNA mismatch repair (MMR), an evolutionarily conserved repair pathway shared by prokaryotic and eukaryotic species alike, influences molecular evolution by detecting and correcting mismatches, thereby protecting genetic fidelity, reducing the mutational load, and preventing lethality. Herein we cond...

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Detalles Bibliográficos
Autores principales: Katju, Vaishali, Konrad, Anke, Deiss, Thaddeus C, Bergthorsson, Ulfar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727991/
https://www.ncbi.nlm.nih.gov/pubmed/34849777
http://dx.doi.org/10.1093/g3journal/jkab364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727991/
https://www.ncbi.nlm.nih.gov/pubmed/34849777
http://dx.doi.org/10.1093/g3journal/jkab364

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