Massively parallel analysis of human 3′ UTRs reveals that AU-rich element length and registration predict mRNA destabilization

AU-rich elements (AREs) are 3′ UTR cis-regulatory elements that regulate the stability of mRNAs. Consensus ARE motifs have been determined, but little is known about how differences in 3′ UTR sequences that conform to these motifs affect their function. Here, we use functional annotation of sequence...

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Detalles Bibliográficos
Autores principales: Siegel, David A, Le Tonqueze, Olivier, Biton, Anne, Zaitlen, Noah, Erle, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728028/
https://www.ncbi.nlm.nih.gov/pubmed/34849835
http://dx.doi.org/10.1093/g3journal/jkab404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728028/
https://www.ncbi.nlm.nih.gov/pubmed/34849835
http://dx.doi.org/10.1093/g3journal/jkab404

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