Aptamer-based factor IXa inhibition preserves hemostasis and prevents thrombosis in a piglet model of ECMO

Extracorporeal membrane oxygenation (ECMO) requires anticoagulation to prevent clotting when the patient’s blood contacts the circuit. Unfractionated heparin (UFH) usually prevents clotting but can cause life-threatening bleeding. An anticoagulant that selectively inhibits the contact activation (in...

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Detalles Bibliográficos
Autores principales: Reed, Christopher R., Bonadonna, Desiree, Otto, James C., McDaniel, Charles Griffin, Chabata, Charlene Vongai, Kuchibhatla, Maragatha, Frederiksen, James, Layzer, Juliana M., Arepally, Gowthami M., Sullenger, Bruce A., Tracy, Elisabeth T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728519/
https://www.ncbi.nlm.nih.gov/pubmed/35036063
http://dx.doi.org/10.1016/j.omtn.2021.12.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728519/
https://www.ncbi.nlm.nih.gov/pubmed/35036063
http://dx.doi.org/10.1016/j.omtn.2021.12.011

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