Cargando…

MicroRNA‐181a restricts human γδ T cell differentiation by targeting Map3k2 and Notch2

γδ T cells are a conserved population of lymphocytes that contributes to anti‐tumor responses through its overt type 1 inflammatory and cytotoxic properties. We have previously shown that human γδ T cells acquire this profile upon stimulation with IL‐2 or IL‐15, in a differentiation process dependen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gordino, Gisela, Costa‐Pereira, Sara, Corredeira, Patrícia, Alves, Patrícia, Costa, Luís, Gomes, Anita Q, Silva‐Santos, Bruno, Ribot, Julie C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728617/ https://www.ncbi.nlm.nih.gov/pubmed/34821000 http://dx.doi.org/10.15252/embr.202052234

Ejemplares similares

MicroRNA-181a/b-1 Is Not Required for Innate γδ NKT Effector Cell Development
por: Sandrock, Inga, et al.
Publicado: (2015)

MicroRNA-181a-5p and microRNA-181a-3p cooperatively restrict vascular inflammation and atherosclerosis
por: Su, Yingxue, et al.
Publicado: (2019)

HER2 Expression in Circulating Tumour Cells Isolated from Metastatic Breast Cancer Patients Using a Size-Based Microfluidic Device
por: Lopes, Cláudia, et al.
Publicado: (2021)

Bordeaux 2018: Wine, Cheese, and γδ T Cells
por: Edelblum, Karen, et al.
Publicado: (2019)

Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation
por: Ribeiro, Sérgio T., et al.
Publicado: (2015)

From thymus to periphery: Molecular basis of effector γδ‐T cell differentiation
por: Fiala, Gina J., et al.
Publicado: (2020)

Expression of receptor activator of NFkB (RANK) drives stemness and resistance to therapy in ER+HER2- breast cancer
por: Gomes, Inês, et al.
Publicado: (2020)

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling
por: Ribeiro, S T, et al.
Publicado: (2017)

MicroRNA-181a regulates IFN-γ expression in effector CD8(+) T cell differentiation
por: Amado, Tiago, et al.
Publicado: (2020)

γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends
por: Barros, Mateus de Souza, et al.
Publicado: (2021)

Therapeutic avenues for γδ T cells in cancer
por: Costa, Gonçalo Palrão, et al.
Publicado: (2023)

Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength
por: Van de Walle, Inge, et al.
Publicado: (2013)

miR-181b/Notch2 overcome chemoresistance by regulating cancer stem cell-like properties in NSCLC
por: Wang, Xiaoyuan, et al.
Publicado: (2018)

Human Natural Killer Cell microRNA: Differential Expression of MIR181A1B1 and MIR181A2B2 Genes Encoding Identical Mature microRNAs
por: Presnell, Steven R, et al.
Publicado: (2014)

MicroRNA Expression Profiles in Autism Spectrum Disorder: Role for miR-181 in Immunomodulation
por: Frye, Richard E., et al.
Publicado: (2021)

Differential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate
por: Garbe, Annette I., et al.
Publicado: (2006)

Integration of T‐cell receptor, Notch and cytokine signals programs mouse γδ T‐cell effector differentiation
por: Zarin, Payam, et al.
Publicado: (2018)

Modulating the Strength and Threshold of NOTCH Oncogenic Signals by mir-181a-1/b-1
por: Fragoso, Rita, et al.
Publicado: (2012)

MicroRNA-181c targets Bcl-2 and regulates mitochondrial morphology in myocardial cells
por: Wang, Hongjiang, et al.
Publicado: (2015)

NFATc1 induction by an intronic enhancer restricts NKT γδ cell formation
por: Giampaolo, Sabrina, et al.
Publicado: (2023)

Regulation of γδT17 cells by Mycobacterium vaccae through interference with Notch/Jagged1 signaling pathway
por: Yao, Yi En, et al.
Publicado: (2020)

Differential Skewing of Circulating MR1-Restricted and γδ T Cells in Human Psoriasis Vulgaris
por: Plužarić, Vera, et al.
Publicado: (2020)

Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo
por: Chen, Edward L.Y., et al.
Publicado: (2021)

Clinical Significance of NOTCH1 and NOTCH2 Expression in Gastric Carcinomas: An Immunohistochemical Study
por: Bauer, Lukas, et al.
Publicado: (2015)

MicroRNA-181c provides neuroprotection in an intracerebral hemorrhage model
por: Lu, Xi, et al.
Publicado: (2020)

Role of MicroRNAs 99b, 181a, and 181b in the Differentiation of Human Embryonic Stem Cells to Vascular Endothelial Cells
por: Kane, Nicole M, et al.
Publicado: (2012)

Notch signaling in mouse blastocyst development and hatching
por: Batista, Mariana R., et al.
Publicado: (2020)

MicroRNA expression profiling and Notch1 and Notch2 expression in minimal deviation adenocarcinoma of uterine cervix
por: Lee, Heejeong, et al.
Publicado: (2014)

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy
por: Legut, Mateusz, et al.
Publicado: (2015)

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
por: Muro, Ryunosuke, et al.
Publicado: (2023)

Identification of Cellular Targets of MicroRNA-181a in HepG2 Cells: A New Approach for Functional Analysis of MicroRNAs
por: Tan, Jane Yi Lin, et al.
Publicado: (2015)

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets
por: Muñoz-Ruiz, Miguel, et al.
Publicado: (2016)

MicroRNA181a Is Overexpressed in T-Cell Leukemia/Lymphoma and Related to Chemoresistance
por: Yan, Zi-Xun, et al.
Publicado: (2015)

MicroRNA-181c Exacerbates Brain Injury in Acute Ischemic Stroke
por: Ma, Qingfeng, et al.
Publicado: (2016)

MicroRNA-181 Variants Regulate T Cell Phenotype in the Context of Autoimmune Neuroinflammation
por: Ghorbani, Samira, et al.
Publicado: (2017)

MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway
por: Wang, Yujing, et al.
Publicado: (2021)

Interleukin‐17‐producing γδ T (γδ17) cells in inflammatory diseases
por: Akitsu, Aoi, et al.
Publicado: (2018)

IL‐23 drives differentiation of peripheral γδ17 T cells from adult bone marrow‐derived precursors
por: Papotto, Pedro H, et al.
Publicado: (2017)

The Aging of γδ T Cells
por: Xu, Weili, et al.
Publicado: (2020)

Inhibiting MicroRNA-503 and MicroRNA-181d with Losartan Ameliorates Diabetic Nephropathy in KKAy Mice
por: Zhu, XinWang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fr75qmpbn22dilosmdnn5nehpp