Decreased dopaminergic inhibition of pyramidal neurons in anterior cingulate cortex maintains chronic neuropathic pain

Pyramidal neurons in the anterior cingulate cortex (ACC), a prefrontal region involved in processing the affective components of pain, display hyperexcitability in chronic neuropathic pain conditions, and their silencing abolishes hyperalgesia. We show that dopamine, through D1 receptor (D1R) signal...

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Detalles Bibliográficos
Autores principales: Lançon, Kevin, Qu, Chaoling, Navratilova, Edita, Porreca, Frank, Séguéla, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728690/
https://www.ncbi.nlm.nih.gov/pubmed/34852233
http://dx.doi.org/10.1016/j.celrep.2021.109933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728690/
https://www.ncbi.nlm.nih.gov/pubmed/34852233
http://dx.doi.org/10.1016/j.celrep.2021.109933

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