TP0586532, a non-hydroxamate LpxC inhibitor, reduces LPS release and IL-6 production both in vitro and in vivo

UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is an essential enzyme in the biosynthesis of Lipid A, an active component of lipopolysaccharide (LPS), from UDP-3-O-acyl-N-acetylglicosamine. LPS is a major component of the cell surface of Gram-negative bacteria. LPS is known to be one of causati...

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Detalles Bibliográficos
Autores principales: Fujita, Kiyoko, Takata, Iichiro, Yoshida, Ippei, Takashima, Hajime, Sugiyama, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728711/
https://www.ncbi.nlm.nih.gov/pubmed/34987187
http://dx.doi.org/10.1038/s41429-021-00498-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728711/
https://www.ncbi.nlm.nih.gov/pubmed/34987187
http://dx.doi.org/10.1038/s41429-021-00498-z

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