Phase 1 trial of ADI‐PEG 20 and liposomal doxorubicin in patients with metastatic solid tumors

BACKGROUND: Arginine depletion interferes with pyrimidine metabolism and DNA damage repair pathways. Preclinical data demonstrated that depletion of arginine by PEGylated arginine deiminase (ADI‐PEG 20) enhanced liposomal doxorubicin (PLD) cytotoxicity in cancer cells with argininosuccinate synthase...

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Detalles Bibliográficos
Autores principales: Yao, Shuyang, Janku, Filip, Koenig, Kimberly, Tsimberidou, Apostolia Maria, Piha‐Paul, Sarina Anne, Shi, Nai, Stewart, John, Johnston, Amanda, Bomalaski, John, Meric‐Bernstam, Funda, Fu, Siqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Clinical Cancer Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729058/
https://www.ncbi.nlm.nih.gov/pubmed/34841717
http://dx.doi.org/10.1002/cam4.4446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729058/
https://www.ncbi.nlm.nih.gov/pubmed/34841717
http://dx.doi.org/10.1002/cam4.4446

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