Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin

Cadherin-mediated cell adhesion requires anchoring via the β-catenin–α-catenin complex to the actin cytoskeleton, yet, α-catenin only binds F-actin weakly. A covalent fusion of VE-cadherin to α-catenin enhances actin anchorage in endothelial cells and strongly stabilizes endothelial junctions in viv...

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Detalles Bibliográficos
Autores principales: Duong, Cao Nguyen, Brückner, Randy, Schmitt, Martina, Nottebaum, Astrid F., Braun, Laura J., Meyer zu Brickwedde, Marika, Ipe, Ute, vom Bruch, Hermann, Schöler, Hans R., Trapani, Giuseppe, Trappmann, Britta, Ebrahimkutty, Mirsana P., Huveneers, Stephan, de Rooij, Johan, Ishiyama, Noboru, Ikura, Mitsuhiko, Vestweber, Dietmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729784/
https://www.ncbi.nlm.nih.gov/pubmed/34851405
http://dx.doi.org/10.1242/jcs.259012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729784/
https://www.ncbi.nlm.nih.gov/pubmed/34851405
http://dx.doi.org/10.1242/jcs.259012

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