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Fine-tuning the spike: role of the nature and topology of the glycan shield in the structure and dynamics of the SARS-CoV-2 S

The dense glycan shield is an essential feature of the SARS-CoV-2 spike (S) architecture, key to immune evasion and to the activation of the prefusion conformation. Recent studies indicate that the occupancy and structures of the SARS-CoV-2 S glycans depend not only on the nature of the host cell, b...

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Detalles Bibliográficos
Autores principales: Harbison, Aoife M., Fogarty, Carl A., Phung, Toan K., Satheesan, Akash, Schulz, Benjamin L., Fadda, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729800/
https://www.ncbi.nlm.nih.gov/pubmed/35126971
http://dx.doi.org/10.1039/d1sc04832e