β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

Alzheimer’s disease is the world’s most common neurodegenerative disorder. It is associated with neuroinflammation involving activation of microglia by β-amyloid (Aβ) deposits. Based on previous studies showing apoptosis-associated speck-like protein containing a CARD (ASC) binding and cross-seeding...

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Detalles Bibliográficos
Autores principales: Friker, Lea L., Scheiblich, Hannah, Hochheiser, Inga V., Brinkschulte, Rebecca, Riedel, Dietmar, Latz, Eicke, Geyer, Matthias, Heneka, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729885/
https://www.ncbi.nlm.nih.gov/pubmed/32187546
http://dx.doi.org/10.1016/j.celrep.2020.02.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729885/
https://www.ncbi.nlm.nih.gov/pubmed/32187546
http://dx.doi.org/10.1016/j.celrep.2020.02.025

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