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β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia
Alzheimer’s disease is the world’s most common neurodegenerative disorder. It is associated with neuroinflammation involving activation of microglia by β-amyloid (Aβ) deposits. Based on previous studies showing apoptosis-associated speck-like protein containing a CARD (ASC) binding and cross-seeding...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729885/ https://www.ncbi.nlm.nih.gov/pubmed/32187546 http://dx.doi.org/10.1016/j.celrep.2020.02.025 |