A purine metabolic checkpoint that prevents autoimmunity and autoinflammation

Still’s disease, the paradigm of autoinflammation-cum-autoimmunity, predisposes for a cytokine storm with excessive T lymphocyte activation upon viral infection. Loss of function of the purine nucleoside enzyme FAMIN is the sole known cause for monogenic Still’s disease. Here we discovered that a FA...

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Detalles Bibliográficos
Autores principales: Saveljeva, Svetlana, Sewell, Gavin W., Ramshorn, Katharina, Cader, M. Zaeem, West, James A., Clare, Simon, Haag, Lea-Maxie, de Almeida Rodrigues, Rodrigo Pereira, Unger, Lukas W., Iglesias-Romero, Ana Belén, Holland, Lorraine M., Bourges, Christophe, Md-Ibrahim, Muhammad N., Jones, James O., Blumberg, Richard S., Lee, James C., Kaneider, Nicole C., Lawley, Trevor D., Bradley, Allan, Dougan, Gordon, Kaser, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730334/
https://www.ncbi.nlm.nih.gov/pubmed/34986329
http://dx.doi.org/10.1016/j.cmet.2021.12.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730334/
https://www.ncbi.nlm.nih.gov/pubmed/34986329
http://dx.doi.org/10.1016/j.cmet.2021.12.009

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