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DNMT1 regulates the timing of DNA methylation by DNMT3 in an enzymatic activity-dependent manner in mouse embryonic stem cells

DNA methylation (DNAme; 5-methylcytosine, 5mC) plays an essential role in mammalian development, and the 5mC profile is regulated by a balance of opposing enzymatic activities: DNA methyltransferases (DNMTs) and Ten-eleven translocation dioxygenases (TETs). In mouse embryonic stem cells (ESCs), de n...

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Detalles Bibliográficos
Autores principales:	Ito, Takamasa, Kubiura-Ichimaru, Musashi, Murakami, Yuri, Bogutz, Aaron B., Lefebvre, Louis, Suetake, Isao, Tajima, Shoji, Tada, Masako
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730390/ https://www.ncbi.nlm.nih.gov/pubmed/34986190 http://dx.doi.org/10.1371/journal.pone.0262277

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