A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans

Glutathione reductase is a critical enzyme for preventing oxidative stress and maintaining a reduced intracellular environment. Almost all present-day humans carry an amino acid substitution (S232G) in this enzyme relative to apes and Neanderthals. We express the modern human and the ancestral enzym...

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Detalles Bibliográficos
Autores principales: Coppo, Lucia, Mishra, Pradeep, Siefert, Nora, Holmgren, Arne, Pääbo, Svante, Zeberg, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730399/
https://www.ncbi.nlm.nih.gov/pubmed/34985944
http://dx.doi.org/10.1126/sciadv.abm1148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730399/
https://www.ncbi.nlm.nih.gov/pubmed/34985944
http://dx.doi.org/10.1126/sciadv.abm1148

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