PCR amplicons identify widespread copy number variation in human centromeric arrays and instability in cancer

Centromeric α-satellite repeats represent ∼6% of the human genome, but their length and repetitive nature make sequencing and analysis of those regions challenging. However, centromeres are essential for the stable propagation of chromosomes, so tools are urgently needed to monitor centromere copy n...

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Detalles Bibliográficos
Autores principales: de Lima, Leonardo Gomes, Howe, Edmund, Singh, Vijay Pratap, Potapova, Tamara, Li, Hua, Xu, Baoshan, Castle, Jemma, Crozier, Steve, Harrison, Christine J., Clifford, Steve C., Miga, Karen H., Ryan, Sarra L., Gerton, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Technology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730464/
https://www.ncbi.nlm.nih.gov/pubmed/34993501
http://dx.doi.org/10.1016/j.xgen.2021.100064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730464/
https://www.ncbi.nlm.nih.gov/pubmed/34993501
http://dx.doi.org/10.1016/j.xgen.2021.100064

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