The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease

DNA-scaffolded enzymes typically show altered kinetic properties; however, the mechanism behind this phenomenon is still poorly understood. We address this question using thrombin, a model of allosterically regulated serine proteases, encaged into DNA origami cavities with distinct structural and el...

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Detalles Bibliográficos
Autores principales: Kosinski, Richard, Perez, Joel Mieres, Schöneweiß, Elisa-C., Ruiz-Blanco, Yasser B., Ponzo, Irene, Bravo-Rodriguez, Kenny, Erkelenz, Michael, Schlücker, Sebastian, Uhlenbrock, Guido, Sanchez-Garcia, Elsa, Saccà, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Physical and Materials Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730604/
https://www.ncbi.nlm.nih.gov/pubmed/34985948
http://dx.doi.org/10.1126/sciadv.abk0425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730604/
https://www.ncbi.nlm.nih.gov/pubmed/34985948
http://dx.doi.org/10.1126/sciadv.abk0425

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