Cargando…

The role of DNA nanostructures in the catalytic properties of an allosterically regulated protease

DNA-scaffolded enzymes typically show altered kinetic properties; however, the mechanism behind this phenomenon is still poorly understood. We address this question using thrombin, a model of allosterically regulated serine proteases, encaged into DNA origami cavities with distinct structural and el...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kosinski, Richard, Perez, Joel Mieres, Schöneweiß, Elisa-C., Ruiz-Blanco, Yasser B., Ponzo, Irene, Bravo-Rodriguez, Kenny, Erkelenz, Michael, Schlücker, Sebastian, Uhlenbrock, Guido, Sanchez-Garcia, Elsa, Saccà, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Physical and Materials Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730604/ https://www.ncbi.nlm.nih.gov/pubmed/34985948 http://dx.doi.org/10.1126/sciadv.abk0425

Ejemplares similares

An allosteric HTRA1-calpain 2 complex with restricted activation profile
por: Rey, Juliana, et al.
Publicado: (2022)

Probing allosteric regulations with coevolution-driven molecular simulations
por: Colizzi, Francesco, et al.
Publicado: (2021)

Programmable allosteric DNA regulations for molecular networks and nanomachines
por: Zhang, Cheng, et al.
Publicado: (2022)

Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions
por: Sprengel, Andreas, et al.
Publicado: (2017)

Aqueous based reflux method for green synthesis of nanostructures: Application in CZTS synthesis
por: Aditha, Sai Kiran, et al.
Publicado: (2015)

Datasets on the corrosion behaviour of nanostructured AISI 316 stainless steel treated by SMAT
por: Olugbade, Temitope
Publicado: (2019)

A simple synthesis method for nanostructured Co-WC/carbon composites with enhanced oxygen reduction reaction activity
por: Kang, Jun, et al.
Publicado: (2016)

Exposed facet-controlled N(2) electroreduction on distinct Pt(3)Fe nanostructures of nanocubes, nanorods and nanowires
por: Tong, Wu, et al.
Publicado: (2020)

Gradient nanostructured steel with superior tensile plasticity
por: Shang, Zhongxia, et al.
Publicado: (2023)

Synthesis of core–shell structured FAU/SBA-15 composite molecular sieves and their performance in catalytic cracking of polystyrene
por: Du, Jinlong, et al.
Publicado: (2017)

Identification of the activity source of CO(2) electroreduction by strategic catalytic site distribution in stable supramolecular structure system
por: Sun, Sheng-Nan, et al.
Publicado: (2020)

AACVD system and protocol to fabricate CuO and Co(3)O(4) nanostructured coatings for application as selective absorbent materials
por: Vázquez-Vargas, D.A., et al.
Publicado: (2023)

A catalytic enantioselective stereodivergent aldol reaction
por: Rahman, Md. Ataur, et al.
Publicado: (2023)

Dataset on constructing colloidal nanoparticles into dry nano-micro-particle (NMP) powders with nanoscale magnetic, plasmonic and catalytic functionalities
por: Chen, Qinglu, et al.
Publicado: (2019)

Three-dimensional femtosecond snapshots of isolated faceted nanostructures
por: Colombo, Alessandro, et al.
Publicado: (2023)

Data related to the PC(71)BM loading and it's impact on nanostructuring for blend of PBDTTT-EFT:PC(71)BM bulk heterojunction solar cell
por: Komilian, Soheil, et al.
Publicado: (2017)

Regiodivergent catalytic asymmetric dearomative cycloaddition of bicyclic heteroaromatics
por: Peng, Lei, et al.
Publicado: (2023)

Nature-inspired catalytic asymmetric rearrangement of cyclopropylcarbinyl cation
por: Li, Qing-Hua, et al.
Publicado: (2023)

Synthesis of hierarchical metal nanostructures with high electrocatalytic surface areas
por: Gloag, Lucy, et al.
Publicado: (2023)

Pumilio2 Promotes Growth of Mature Neurons
por: Schieweck, Rico, et al.
Publicado: (2021)

Plus and minus ends of microtubules respond asymmetrically to kinesin binding by a long-range directionally driven allosteric mechanism
por: Vu, Huong T., et al.
Publicado: (2022)

Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases
por: Gable, Jonathan E., et al.
Publicado: (2014)

A closed-loop catalytic nanoreactor system on a transistor
por: Wang, Xuejun, et al.
Publicado: (2023)

Cryogenic study of the magnetic and thermal stability of retained austenite in nanostructured bainite
por: Argüelles, Arántzazu, et al.
Publicado: (2019)

Versatile computer-aided design of free-form DNA nanostructures and assemblies
por: Pfeifer, Wolfgang G., et al.
Publicado: (2023)

Catalytic resonance of ammonia synthesis by simulated dynamic ruthenium crystal strain
por: Wittreich, Gerhard R., et al.
Publicado: (2022)

A crystal glass–nanostructured Al-based electrocatalyst for hydrogen evolution reaction
por: Liu, Sida, et al.
Publicado: (2022)

Photolithographic realization of target nanostructures in 3D space by inverse design of phase modulation
por: Nam, Sang-Hyeon, et al.
Publicado: (2022)

Ambient-pressure lignin valorization to high-performance polymers by intensified reductive catalytic deconstruction
por: O’Dea, Robert M., et al.
Publicado: (2022)

Highlight report: Software for tissue analysis and reconstruction
por: Haridy, Mohie A. M., et al.
Publicado: (2015)

Catalytic transfer hydrogenation of N(2) to NH(3) via a photoredox catalysis strategy
por: Johansen, Christian M., et al.
Publicado: (2022)

PPI-Affinity: A Web Tool for the Prediction and Optimization of Protein–Peptide and Protein–Protein Binding Affinity
por: Romero-Molina, Sandra, et al.
Publicado: (2022)

Nucleation as a rate-determining step in catalytic gas generation reactions from liquid phase systems
por: Solymosi, Thomas, et al.
Publicado: (2022)

Synthesis of novel hexamolybdenum cluster-functionalized copper hydroxide nanocomposites and its catalytic activity for organic molecule degradation
por: Nguyen, Thi Kim Ngan, et al.
Publicado: (2021)

Fundamental mechanistic insights into the catalytic reactions of Li─S redox by Co single-atom electrocatalysts via operando methods
por: Xu, Weixuan, et al.
Publicado: (2023)

Allosteric Hotspots in the Main Protease of SARS-CoV-2
por: Strömich, Léonie, et al.
Publicado: (2022)

Allosteric inhibitors of the main protease of SARS-CoV-2
por: Samrat, Subodh Kumar, et al.
Publicado: (2022)

Tests confirm antiviral properties of selected Sanitized additives on polymer surfaces
Publicado: (2020)

Tosaf formulates antiviral and antimicrobial additive for nonwoven medical protection products
Publicado: (2020)

Data related to the mesoscopic structure of iso-graphite for nuclear applications
por: März, Benjamin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mucqcmitk2lqbr1fnh3pe8eejt