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Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus
When a neurotrophin binds at the presynapse, it sends survival signals all the way to the nucleus on signaling endosomes. These endosomes fuel their own journey with on-board glycolysis—but how is that journey initiated and maintained? Using microfluidic devices and mice, we find that the calcium re...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730605/ https://www.ncbi.nlm.nih.gov/pubmed/34985962 http://dx.doi.org/10.1126/sciadv.abj8812 |